CHI3L1 - a novel myokine
نویسندگان
چکیده
منابع مشابه
Irisin, a novel myokine: potential role in obesity and diabetes
Obesity is a worldwide health problem that results in a signifi cant increased risk of morbidity and mortality. While we know that obesity is the consequence of a chronic imbalance between energy intake and energy expenditure, how energy expenditure is regulated in humans is not clearly understood. Recent publications suggest that specifi c depots of white adipose tissue can be converted to the...
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The myokine irisin is supposed to be cleaved from a transmembrane precursor, FNDC5 (fibronectin type III domain containing 5), and to mediate beneficial effects of exercise on human metabolism. However, evidence for irisin circulating in blood is largely based on commercial ELISA kits which are based on polyclonal antibodies (pAbs) not previously tested for cross-reacting serum proteins. We hav...
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Current treatment methods for patients diagnosed with gliomas have shown limited success. This is partly due to the lack of prognostic genes available to accurately predict disease outcomes. The aim of this study was to investigate novel prognostic genes based on the molecular profile of tumor samples and their correlation with clinical parameters. In the current study, microarray data (GSE4412...
متن کاملNovel myokine: irisin may be an independent predictor for subclinic atherosclerosis in Behçet's disease.
Behçet's disease (BD) is a vasculitic and inflammatory disease causing endothelial dysfunction. Irisin is a metabolic hormone related to insulin resistance and endothelial functions. In this study, we investigated the relationship between irisin and carotid intima-media thickness (cIMT), which is a marker of atherosclerosis in patients with BD. 48 patients with BD and 50 healthy individuals wer...
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The cytokine leukemia inhibitory factor (LIF) is expressed by skeletal muscle and induces proliferation of myoblasts. We hypothesized that LIF is a contraction-induced myokine functioning in an autocrine fashion to activate gene regulation of human muscle satellite cell proliferation. Skeletal muscle LIF expression, regulation, and action were examined in two models: 1) young men performing a b...
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ژورنال
عنوان ژورنال: Acta Physiologica
سال: 2015
ISSN: 1748-1708
DOI: 10.1111/apha.12616